Custom Peptides
Cayman Chemical TamInadent 10mg
An adenosine A2A receptor antagonist (Ki = 12 nM); selective for adenosine A2A receptors over adenosine A1-, A2B-, and A3 receptors (Kis = 2,500, 1,000, and 5,000 nM, respectively); increases the levels of IFN-γ secreted by tumor-associated T cells isolated from patient-derived lung tumors at 1 µM when used in combination with an antibody targeting PD-1 or PD-L1; reduces the number of lung nodules in an MCA-205 murine fibrosarcoma model of lung metastasis at 15 mg/kg per day; inhibits haloperidol-induced catalepsy in a rat model of Parkinson's disease motor symptoms at 3, 10, or 30 mg/kg
Cayman Chemical Maltopentaose 10mg
An oligosaccharide comprised of five α-1,4-linked glucose molecules; increases the α-amylase synthesis rate in B. stearothermophilus at 1 mM; has been used as a substrate for PPA to study various inhibitors of PPA
Cayman Chemical ComplnatusIde 10mg
A flavonoid glucoside; inhibits NO production in LPS-stimulated RAW 264.7 cells (IC50 = 21.2 μM)
Cayman Chemical 2-O-GaloylhyperIn 10mg
A natural flavonoid; scavenges DPPH and ABTS radicals (IC50s = 3 and 3.5 μM, respectively); inhibits human OATP1B1 (IC50 = 19 μM in HEK293 cells); decreases LPS-induced IL-6 and TNF-α cytokine production from mouse RAW 264.7 macrophages at 15 μM; decreases LPS-induced mortality and liver damage in a mouse model of septic shock at 50 mg/kg
Cayman Chemical ChrysoerIol 10mg
A flavonoid; active against E. faecalis, B. subtilis, S. aureus, P. aeruginosa, K. pneumoniae, and E. coli (MICs = 0.06-1 UG/ml); induces cell cycle arrest at the G1 phase and autophagy in A549 lung cancer cells at 7.5, 15, and 30 µM; reduces LPS-induced production of IL-6, IL-1β, and TNF-α in RAW 264.7 cells at 20 µM; reduces plasma glucose, total cholesterol, free fatty acid, and phospholipid levels in an STZ-induced rat model of diabetes
Cayman Chemical MTP 131acetate 10mg
A mitochondria-targeted peptide antioxidant; reduces tert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells from 0.001 to 1 nM; reduces infarct volume, hemispheric swelling, and GSH depletion in a mouse model of MCAO-induced acute cerebral ischemia at 2 mg/kg; increases survival, improves motor function, and decreases degeneration of the lumbar spinal cord in the SOD1G93A transgenic mouse model of ALS at 5 mg/kg; reduces albuminuria, urinary hydrogen peroxide levels, and mesangial matrix accumulation, as well as preserves superoxide production, in a db/db mouse model of diabetic nephropathy
Cayman Chemical 20 S-ProtopnaxadIol 10mg
A sapogenin; cytotoxic to MT-4 human T cell leukemia cells (CC50 = 7.2 µM); inhibits the growth of human A549 human lung carcinoma, SKOV3 ovarian adenocarcinoma, SK-MEL-2 melanoma, and K562 chronic leukemia cells (EC50s = 9.8-20 µM), as well as P388 and L1210 murine leukemia cells (EC50s = 9.8 and 10, respectively); inhibits the growth of H. pylori in vitro (MIC = 50 UG/ml)
Cayman Chemical SemaglutIde MaIn ChaIn937 10mg
A peptide starting material in the synthesis of semaglutide
Cayman Chemical FaropenmsodIM salt hydrat 10mg
A penem antibiotic; active against a panel of 12 Gram-positive (MIC50s = 0.008-1 mg/L) and 15 Gram-negative (MIC50s = 0.06-16 mg/L) bacteria; reduces the number of lung CFUs in a mouse model of H. influenzae-induced respiratory tract infection
Cayman Chemical PalmItoylcholInchlorIde 10mg
An acyl choline; inhibits protein kinase C activity at 100 μM; induces hemolysis in rat erythrocytes; plasma levels are decreased in female patients with ME/CFS
Cayman Chemical TenapnorhydrochlorIde 10mg
An orally bioavailable NHE-3 inhibitor (IC50 = 10 nM for the recombinant rat protein); inhibits intestinal fluid absorption in mouse jejunum, but not distal colon, in a closed intestine loop assay at 10 µM; lowers both the sodium and phosphate urinary-to-dietary ratio in a dose-dependent manner in rats; reverses loperamide-induced decreases in stool pellet numbers and water content and prevents loperamide-induced constipation in mice at 5 mg/kg
Cayman Chemical SencIo cInrarIa MareIn 10mg
A glucoside chalcone; scavenges DPPH radicals (IC50 = 48.35 μM); inhibits EGFR (IC50 = 19.94 μM); reduces fasting blood glucose and fasting serum insulin, triglycerides, LDL cholesterol, total cholesterol, IL-6, and CCL2 levels and renal IL-6 and CCL2 levels, as well as decreases fibrosis, in diabetic db/db mice at 50 mg/kg