Custom Peptides
Cayman Chemical EltoprazInhydrochlorIde 10mg
A partial agonist at 5-HT1A, 5-HT1B, and 5-HT2B receptors (Kis = 40, 52, and 81 nM, respectively); decreases aggressive behavior in resident-intruder tests with rats (ID50 = 0.24 mg/kg)
Cayman Chemical MS023hydrochlorIde 10mg
An inhibitor of type I PRMTs (IC50s = 30, 119, 83, 4, and 5 nM for PRMT1, -3, -4, -6, and -8, respectively); selective for these type I PRMTs over PRMT5, -7, and -9, as well as a panel of 25 PKMTs and DNMTs at 10 µM; inhibits methylation of H4R3 in MCF-7 cells and H3R2 in HEK293 cells (IC50s = 9 and 56 nM, respectively); inhibits methylation of the SARS-CoV-2 nucleocapsid protein and the replication of SARS-CoV-2 in Vero E6 cells at 20 µM; reduces tumor growth in a Huh7 mouse xenograft model at 160 mg/kg
Cayman Chemical DIhydromyrIstIcIn 10mg
A derivative of myristicin; induces GST activity in the liver and small intestinal mucosa but not the forestomach, lungs, large intestinal mucosa, or bladder in mice at 20 mg/animal
Cayman Chemical Agomelatn 10mg
A melatonin receptor agonist (Kis = 0.14 and 0.41 nM for MT1 and MT2, respectively) and 5-HT2B and 5-HT2C antagonist (Kis = 0.26 and 0.71 nM, respectively); inhibits the 5-HT2-mediated penile erection response in rats at 40 mg/kg; increases extracellular levels of noradrenaline and dopamine in the frontal cortex of freely moving rats at 20-80 mg/kg; reduces immobility time in the forced swim test and increases the amount of time spent in the open arms of the elevated plus maze in mice in a transgenic neuroendocrine model of depression at 10 mg/kg
Cayman Chemical LIfItegrast 10mg
An inhibitor of the LFA-1/ICAM-1 interaction; binds to LFA-1 and blocks the adhesion of Jurkat T cells or HuT 78 cells to ICAM-1 (IC50s = 2.98 and 9 nM, respectively) and inhibits secretion of various cytokines from these cells; increases tear production in dogs with idiopathic keratoconjunctivitis sicca; topical application inhibits LFA-1-dependent neutrophil recruitment to the eye in mouse models of contact lens-associated corneal inflammation induced by corneal abrasion and tobramycin-killed bacteria
Cayman Chemical StaurosporIn 10mg
A potent inhibitor of PKC (IC50 = 2.7 nM for the rat brain enzyme)
Cayman Chemical FFN102trIfluoroACTAte sal 10mg
A pH-dependent fluorescent probe to label dopaminergic cells; excitation spectra of 340 and 370 nm at pH 5 and 7.4, respectively, which correspond to vesicular and cytoplasmic pH values; emission spectrum of 453 nm, with a higher intensity at pH 7.4; inhibits DAT (13.6% at a concentration of 10 µM) and the 5-HT receptor subtype 5-HT2c (Ki = ~3 µM); does not bind to 37 central nervous system receptors, including dopamine and serotonin receptors, up to a concentration of 10 µM
Cayman Chemical Phylnthus urnara Grn 10mg
A tannin with diverse biological activities; scavenges DPPH (IC50s = 0.92 and 1.27 μM at pH 4.5 and 7.9, respectively), superoxide (IC50 = 2.65 μM), and hydroxyl radicals (IC50 = 1.44 μM) in cell-free assays; inhibits HSV-1 and HSV-2 replication in plaque reduction assays (IC50s = 35 and 18.4 μM, respectively); inhibits ACE (IC50 = 13.22 μM); reduces both systolic and diastolic blood pressure in spontaneously hypertensive rats at 5 mg/kg; induces apoptosis and halts the cell cycle at the S phase in A549 lung cancer cells at 5, 10, and 20 μM; reduces tumor growth in an A549 mouse xenograft model at 10 and 20 mg/kg
Cayman Chemical BufuralolhydrochlorIde 10mg
A non-selective antagonist of β-ARs that also has partial agonist activity; decreases mean arterial blood pressure and increases abdominal aortic blood flow in anesthetized cats at 0.3 and 1 mg/kg; has been used as a substrate to measure CYP2D6 activity
Cayman Chemical CGS 21680hydrochlorIde 10mg
A potent, selective agonist of the adenosine A2A receptor (Ki = 11-46 nM); less effective at adenosine A1 and A3 receptors (Kis = 0.5-3.1 and 0.6-1 µM, respectively) and is without effect at adenosine A2B (Ki > 10 µM)
Cayman Chemical 17trIfluoromthylphnyl13 1 10mg
A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma.{8941,9341,8839} Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.{9736} 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α would act very much like the free acid of latanoprost.
Cayman Chemical 5a 6-DIhydroxycholestnol 10mg
An oxysterol metabolite of cholesterol; inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors; binds to Nav channels and decreases action potentials in hippocampal neurons in vitro at 10 µM; increases survival of spinal cord motoneurons, cortical neurons, and cerebellar granule neurons in vitro at 5-15 µM; neuroprotective in a rat model of cerebral ischemia at 12 mg/kg ; increases latency to seizure onset and reduces severity of PTZ-induced seizures in rats; has been used as a replacement for cholesterol in the study of cholesterol binding proteins
Cayman Chemical S-PhenylcysteIn 10mg
An adduct; formed by the binding of benzene oxide to cysteine residues in hemoglobin; has been found in red blood cells isolated from benzene-exposed rats and mice
Cayman Chemical Corynoln 10mg
An isoquinoline alkaloid with diverse biological activities; an inhibitor of acetylcholinesterase (IC50 = 30.6 µM); an inhibitor of BACE1 (IC50s = 33.59 and 89.07 µM for FRET and immobilized enzyme reactive assays, respectively); decreases LPS-induced NF-κB activation and reverses LPS-induced decreases in Nrf2 and HO-1 protein levels in HUVECs; increases the survival rate in a mouse model of LPS- and heat-killed E. coli-induced sepsis at 10, 20, and 40 mg/kg; selectively inhibits proliferation of B16/F10 mouse and A375 human melanoma cells (IC50s = 12.87 and 10.47 µM, respectively) over non-cancerous melanocytes (IC50 = 126.61 µM); reduces tumor growth in a B16/F10 mouse melanoma model at 20 mg/kg
Cayman Chemical 3-AcetylursolIc AcId 10mg
A triterpene with diverse biological activities; inhibits ADP-, thrombin-, or epinephrine-induced aggregation of isolated rat platelets (IC50s = P. falciparum in vitro (IC50 = 4 µM); active against B. cereus, S. aureus, and S. pneumoniae (MICs = 39.1, 19.6, and 4.81 µM, respectively); cytotoxic to HepG2 cells (LC50 = 351 µM)